Efficacy of plasma exchange in neonatal very severe hyperbilirubinemia
血浆置换治疗新生儿极重度高胆红素血症疗效

摘要

目的 观察血浆置换疗法在新生儿极重度高胆红素血症的疗效。方法 病例是新生儿极重度高胆红素血症患者，共88例，时间2021年5月至2022年6月。常规治疗组（44例）：实施常规疗法治疗。血浆置换+常规治疗组（44例）：除常规治疗外，实施血浆置换治疗。研究效果。结果 血浆置换+常规治疗组的临床病情控制优良率更高[95.46%（42/44），同常规治疗组的77.27%（34/44）比较]（p＜0.05）。血浆置换+常规治疗组治疗3、5d后的总胆红素浓度更低[（255.17±51.39）umoL/L、（215.39±45.16）umoL/L，分别同常规治疗组的、（348.17±74.11）umoL/L、（295.74±65.18）umoL/L比较]（p＜0.05）。血浆置换+常规治疗组治疗3、5d后的间接胆红素浓度均更低[（244.09±48.05）umoL/L、（217.25±40.39）umoL/L，分别同常规治疗组的（298.44±69.11）umoL/L、（268.33±62.05）umoL/L比较]（p＜0.05）。血浆置换+常规治疗组治疗5d后的血小板浓度、血糖浓度未明显变化[（243.15±100.43）×109/L、（4.87±0.26）mmol/L，分别同治疗前的（244.67±101.14）×109/L、（4.83±0.15）mmol/L比较]（p＞0.05）。结论 对新生儿极重度高胆红素血症患者，实施血浆置换治疗，可实现更佳疗效。

Abstract

Objective To observe the efficacy of plasma exchange therapy in extremely severe hyperbilirubinemia.
Methods Cases were 88 neonatal patients with extremely severe hyperbilirubinemia, and were recorded from May 2021 to June 2022. Conventional therapy group (44 patients): conventional therapy therapy. Plasmapheresis + conventional treatment group (44 patients): in addition to conventional therapy. research effect.
Results A higher rate of excellent clinical condition control [95.46% (42 / 44), compared with 77.27% (34 / 44) in the conventional treatment group] (p <0.05). The total bilirubin concentration was lower after 3 and 5d [(255.17±51.39) umuo L / L, (215.39±45.16) umL / L, (348.17±74.11) umo L / L, (295.74 ± 65.18) umo L / L) in the conventional group) (p <0.05). The indirect bilirubin concentrations were lower after 3 and 5d [(244.09±48.05) umuo L / L, (217.25±40.39) umuo L / L versus (298.44±69.11) umo L / L, (268.33 ± 62.05) umo L / L), respectively) (p <0.05). The platelet concentration and blood glucose concentration after 5d [(243.15±1009 / L, (4.87±0.26) mmol/L, compared with (244.67±101.14) 109 / L, (4.8 3±0.15) mmol/L before treatment)] (p> 0.05).
Conclusion   For patients with very severe hyperbilirubinemia.