Effect of diabetes mellitus in pregnancy on myocardial enzymes and renal function in neonates
妊娠期糖尿病对新生儿心肌酶谱及肾功能指标的影响观察

摘要

目的 对临床上妊娠期糖尿（GDM）病患者对新生儿心肌酶谱及肾功能指标的影响进行探讨。方法 随机抽取100例2021年1月-2023年1月间来我院分娩的GDM患者新生儿作为研究对象，将该组设置为A组，组内早产儿及足月儿分别有64例（A1组）和36例（A2组），结合产前患者血糖控制情况将其的划分为控制组68例及未控制组32例；此外以同期来我院生产的健康女性所生新生儿100例作为B组，该组中早产儿和足月儿分别有48例（B1组）和52例（B2组）。对A组和B组、A1和A2两组、B1和B2两组、控制组与未控制组两组之间的新生儿心肌酶谱及肾功能指标等进行对比。结果 根据乳酸脱氢酶（LDH）、血尿素氮（BUN）、肌酐（CREA）胱抑素C（Cys-C）、肌酸激酶同工酶（CK-MB）等检测结果显示，A、A1、A2三组的各项指标明显高于B、B1、B2等三组，差异显著，P<0.05。且相较于未控制组，控制组新生儿在CREA、Cys-C、BUN等质指标方面明显更低，差异显著，P<0.05。结论 对于GDM患者来说新生儿有很大概率会出现心、肾损伤等疾病，在妊娠期如能合理控制血糖，可以有效降低新生儿的心、肾功能损伤情况。

Abstract

Objective To investigate the clinical effect of gestational diabetes mellitus (GDM) on neonatal myocardial zymogram and renal function.
Methods 100 neonates with GDM delivered in our hospital from January 2021 to January 2023 were randomly selected as the study object. The group was divided into group A, 64 premature infants and 36 full-term infants in the group (group A1) and 36 full-term infants (group A2), respectively. According to the blood glucose control status of prenatal patients, they were divided into control group (68 cases) and uncontrolled group (32 cases); In addition, 100 newborns born to healthy women in our hospital during the same period were taken as group B. There were 48 premature infants and 52 full-term infants in this group (group B1) and 52 (group B2), respectively. The myocardial zymogram and renal function indexes of neonates between groups A and B, A1 and A2, B1 and B2, control group and uncontrolled group were compared.
Results According to the test results of lactate dehydrogenase (LDH), blood urea nitrogen (BUN), creatinine (CREA), cystatin C (Cys-C) and creatine kinase isoenzyme (CK-MB), the indexes of group A, A1 and A2 were significantly higher than those of group B, B1 and B2, with significant difference (P<0.05). Compared with the uncontrolled group, the control group newborns had significantly lower quality indicators such as CREA, Cys-C, BUN, and the difference was significant (P<0.05).
Conclusion   For GDM patients, there is a high probability that the newborn will have heart and kidney injury and other diseases. If the blood sugar can be reasonably controlled during pregnancy, the heart and kidney function injury of the newborn can be effectively reduced.