Evaluation of systemic mild hypothermia in neonatal asphyxia
有关全身亚低温在新生儿窒息中的应用效果评估

摘要

目的 评估有关全身亚低温在新生儿窒息中的应用效果。方法 应用医学实验调查分析法，选取我院2022年1月至2023年1月以来收治的50例新生儿窒息患儿作为实验样本，按照治疗环节方法差异，随机等分为两组，给予对照组采用常规复苏抢救治疗，给予治疗组联合有关全身亚低温治疗，评估两组临床疗效及其对患者预后的影响。结果 治疗组患儿临床疗效96.00%（24/25）显著高于对照组的80.00%（20/25），有统计学对比意义（P<0.05）。治疗组患儿在乳酸脱氢酶（LDH）、血肌酐（SCr）、谷丙转氨酶（ALT）、空腹血糖、血清肌酸激酶（CKMD）活性上显著优于对照组，有统计学对比意义（P<0.05）。结论 有关全身亚低温治疗新生儿窒息的临床有效性和安全性较高，凸显在治疗后可明显提升疗效，改善患儿预后，值得临床加以推广实施。

Abstract

Objective To evaluate the effects of systemic mild hypothermia on neonatal asphyxia.
Methods Fifty children with neonatal asphyxia admitted to our hospital from January 2022 to January 2023 were selected as experimental samples. According to the differences in treatment procedures, they were randomly divided into two groups: the control group received conventional resuscitation treatment, and the treatment group combined with systemic mild hypothermia treatment. The clinical efficacy and prognosis of the two groups were evaluated.
Results The clinical effect in the treatment group was 96.00% (24/25) significantly higher than that in the control group (80.00% (20/25), with statistical significance (P<0.05). The activities of lactate dehydrogenase (LDH), serum creatinine (SCr), alanine aminotransferase (ALT), fasting blood glucose and serum creatine kinase (CKMD) in the treatment group were significantly better than those in the control group, with statistical significance (P<0.05).
Conclusion   The clinical efficacy and safety of systemic mild hypothermia in the treatment of neonatal asphyxia are relatively high, which shows that the therapeutic effect can be significantly improved after treatment and the prognosis of children can be improved. It is worthy of clinical promotion and implementation.